Ashwagandha. LiverTox: Clinical and research information on drug-induced liver injury. Bethesda, MD: National Institute of Diabetes and Digestive and Kidney Diseases; 2019. Accessed at ncbi.nlm.nih.gov/books/NBK548536 on July 6, 2022.
Ashwagandha. Natural Medicines website. Accessed at naturalmedicines.therapeuticresearch.com on July 6, 2022. [Database subscription].
Ashwagandha may be safe when taken in the short term (up to 3 months). There is not enough information to allow conclusions about its long-term safety to be reached.
In some individuals, ashwagandha preparations may cause drowsiness, stomach upset, diarrhea, and vomiting.
Although it is rare, there have been a number of cases that link liver injury to ashwagandha supplements.
Ashwagandha should be avoided during pregnancy and should not be used while breastfeeding.
Ashwagandha is not recommended for people who are about to have surgery, or for those who have autoimmune or thyroid disorders.
There is evidence that ashwagandha might interact with some medications, including those for diabetes and high blood pressure, medicines that decrease the immune system response (immunosuppressants), sedatives, anti-seizure medications (anticonvulsants), and thyroid hormone medications.
Because ashwagandha may increase testosterone levels, people with hormone-sensitive prostate cancer should avoid its use.
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